Intermenstrual bleeding

Definition/Description

Vaginal bleeding (other than post coital) at any time in the cycle other than during normal menstruation.
 

Red Flag Symptoms

  • Postmenopausal Bleeding (PMB) i.e. bleeding >12 months after last period. PMB pathway
  • Suspicious cervix on examination. Refer 2WW
  • Persistent Intermenstrual bleeding (IMB) if >40 or other risk factors for endometrial cancer. (eg obesity, PCOS, unopposed oestrogen, tamoxifen) refer urgently and request USS

Guidelines on Management

  • If more than 3 episodes of IMB; organize examination and swabs
  • Remember chlamydia in under 25s.
  • If any abnormality on pelvic examination: pelvic mass- organise USS.
  • If swabs and examination are normal- trial of treatment: Mirena/COCP/ POP for 3 months.
  • If women already on hormonal contraception unscheduled bleeding is common with all forms of hormonal contraception during the first 3 months of use, consider trialling a different hormonal preparation after this time
  • Failure to respond to standard therapy - consider referral for hysteroscopy

Referral Criteria/Information

  • Indications for referral
    • Failure to response to the above therapies
  • Information to include in referral letter
    • Describe problem and length of symptoms.
    • Current Contraception
    • Smear history (including last smear & result) the patient will still be seen without this but if you can retrieve it automatically it speeds up the consultation. Do not perform smear outside of screening programme.
    • Relevant past medical/surgical history
    • Current regular medication
    • BMI/smoking status
    • Speculum findings (e.g. normal/ectropion/ cervicitis/cervical polyp)
    • Swab results; chlamydia and HVS
    • USS result
    • Treatments tried so far

Additional Resources & Reference

Patient information leaflets/ PDAs

NHS leaflet: What causes bleeding between periods?

 

References

NICE Guideline Heavy Menstrual Bleeding: assessment and management (NG 88)

NICE Guideline: Suspected cancer: recognition and referral (NG12)

Joint RCOG, BSGE and BGCS guidance for the management of abnormal uterine bleeding in the evolving Coronavirus (CQVID-19) pandemic

Author: Responsible GP: Dr Jacgui Cain / Responsible Consultant: Miss Vijaianitha Nallendran
Date created: 17/06/2025, 15:39
Last modified: 09/07/2025, 14:25
Date of review: 31.08.26