Cancer of unknown primary (MUO)

Definition/Description

Create and process referral request via Gateway

Red Flag Symptoms

  • Multiple lung metastases on CXR/CT (unless Radiology indicates lung primary)
  • Multiple brain metastases on CT/MRI Multiple liver metastases on USS/CT/MRI
  • Multiple bone metastases on XR/CT/MRI/bone scan (PSA not raised)
  • Widespread peritoneal infiltration +/-ascites on USS/CT (CA125 not raised)
  • Other disseminated disease on scan and no site of primary identified (discuss with oncology)

Guidelines on Management

If your patient does not meet any of the NICE defined USC criteria please liaise (by phone or Advice and Guidance) with a specialist or send them in as an urgent referral. Please do not annotate USC forms with your own criteria.

Patient awareness

  • Confirm that your patient understands that they have been referred onto a “suspected cancer pathway”
  • Confirm that your patient has received the information leaflet
  • Confirm that your patient is available to attend an appointment within 2 weeks of this referral
  • Confirm that the patient’s renal function (Urea and electrolytes) has been requested and the patient is aware to have the sample taken urgently, to expedite the request for CT Thorax, abdomen and pelvis with contrast

For advice please contact Oncology on call or Acute Oncology Nurses on 01904 724519
 

An alternative referral form should be used for the following results:

  • Radiology indicates lung primary - use Suspected Lung Cancer form
  • Multiple bone metastases on XR/CT/MRI/bone scan (PSA raised) - use Suspected Urological Cancer form
  • Widespread peritoneal infiltration +/-ascites on USS CT (CA125 raised) - use Suspected Gynaecological Cancer form

Referral Criteria/Information

Additional Resources & Reference

Associated Policies

There are no associated policies.

Places covered by

  • Vale of York

Hospital Trusts

  • York and Scarborough Teaching Hospitals
Author:
Date created: 28/08/2025, 13:48
Last modified: 09/09/2025, 10:52
Date of review: