Suspected cancer of unknown primary
Definition/Description
This is a LESION BASED, not symptom only, pathway. Patients with unexplained anaemia, weight loss or fatigue not associated with a mass/lesion on imaging should not be referred via this route.
Red Flag Symptoms
- Multiple lung metastases on CXR/CT
- Multiple brain metastases on CT/MR
- Multiple liver metastases on USS/CT/MRI with no obvious primary. [Normal AFP and normal CXR required pre-referral]
- Solitary or multiple bone metastases on XR/CT/MRI/bone scan with no obvious primary. [Normal PSA (in men), negative myeloma screen and normal CXR required pre-referral]
- Disseminated suspected malignancy on imaging and no site of primary identified
- Widespread peritoneal infiltration +/- ascites on USS/CT
Guidelines on Management
Multiple lung metastases on CXR/CT
If radiology indicates lung primary then refer to suspected respiratory cancer pathway
Widespread peritoneal infiltration +/- ascites on USS/CT
If CA125 raised then refer to suspected gynaecological cancer
Referral Criteria/Information
Refer as a USC if has any of the Red Flag Symptoms listed.
(See flowchart below)
Associated Policies
There are no associated policies.
Specialties
Places covered by
- North Yorkshire
Hospital Trusts
Harrogate and District
Date created: 03/03/2026, 14:58
Last modified: 03/03/2026, 16:43
Date due for review: 3/3/26