Direct access upper GI endoscopy
Definition/Description
Direct Access Upper GI endoscopy
Red Flag Symptoms
See suspected upper GI cancer pathway
Guidelines on Management
NICE non-urgent criteria to exclude cancer
- Haematemesis
- People aged 55 or over with:
- treatment-resistant dyspepsia (see 2) OR
- upper abdominal pain** with low haemoglobin levels OR
- raised platelet count with any of the following:
- nausea
- vomiting
- weight loss*
- reflux
- dyspepsia
- upper abdominal pain**, OR
- nausea or vomiting with any of the following:
- weight loss*
- reflux
- dyspepsia
- upper abdominal pain**
Reflux symptoms
- Lifestyle advice and offer full dose of PPI for 4-8 weeks
- If symptoms recur after initial treatments:
- use lowest dose possible of PPI
- offer H2RA therapy if idequate response to PPI
- If response adequate no need for endoscopy. Proceed to open access upper GI endoscopy only if inadequate response.
Non Reflux/dyspepsia symptoms
Lifestyle advice, review medication (e.g. NSAID). Offer one of:
- 1 month trial of PPI
OR - H Pylori Testing: Use stool antigen test Leave a 2 week washout period after PPI
- H pylori positive and symptomatic
- Eradication therapy – see NICE/CKS/BNF
- Still symptomatic - retest with stool antigen test (ideally 4-8 weeks post-treatment)
- Second line therapy – see NICE/CKS/BNF. Aim to use antibiotics patient not previously exposed to
- H pylori not known or negative but still symptomatic
- Empirical full dose PPI for 4 weeks OR If H.Pylori not yet tested and trial of PPI unsuccessful, test for H.Pylori
- H pylori positive and symptomatic
- If response adequate no need for endoscopy. Proceed to open access upper GI endoscopy only if inadequate response.
Other indications
Urgent +/- OPA:
- Persistent vomiting
- Previous complicated ulcer
- Previous gastric ulcer
- Continuing need for NSAIDS
Routine
- IDA if does not meet 2ww criteria
- Suspected malabsorption
*weight loss in over 55 with reflux or dyspepsia or upper abdo pain = 2ww referral
**Upper abdominal pain in absence of weight loss may require routine abdominal imaging (U/S) and/or upper GI endoscopy if persistent and unexplained
**Upper abdominal pain in absence of weight loss may require routine abdominal imaging (U/S) and/or upper GI endoscopy if persistent and unexplained
Referral Criteria/Information
Consider for patients who do not meet the criteria for upper GI USC referral and meet the following criteria:
- Meet NICE non-urgent criteria to exclude cancer (ensure patients do not otherwise meet full USC guidance)
- Treatment failure (see 'guidelines on management' section) in reflux or dyspepsia any age
- Other indications
NB: If patient has had a previous endoscopy in the last 3-5 years with non-reflux symptoms, no new pattern of symptoms and no new alarm signs then base management on previous endoscopic findings and consider H pylori testing
Associated Policies
There are no associated policies.
Places covered by
- North Yorkshire
Hospital Trusts
Harrogate and District
Date created: 04/03/2026, 11:11
Last modified: 04/03/2026, 11:17
Date due for review: 3/4/27